image

Total synthesis of Tamiflu:
Reference: Ishikawa, H.; Suzuki, T.; Hayashi, Y. ACIEE 2009, 48, 1307 DOI
Keywords: ConjAdd EnAmine • EneNitro+EnAmine(asym) • EnAmine+EneNitro(asym) • ConjAdd Nitronate • Nitronate+EnoateEster • HWE → EnoateEster (intram) • Cyclohexene • CarboxAcid → CarboxCl • CarboxCl → CarboxAzide • Curtius • C-CO2H → C-N • Nitro → Amine • Dehydrosulfenylation → EnoateEster • CarboxEster → CarboxAcid • ConjAdd M-SR •
Reagents: Pyrrolidine • Chloroacetate • EnePhosphonate • Carbonate, cesium • P(O)(OR)2CH2-C(O)OR' • Thiol, tolyl • Acetic acid, trifluoro • Oxalyl chloride • DMF (solvent) • Azide, sodium • Acetic anhydride • SiMe3-Cl • NH3 • Carbonate, potassium • Chiral catalyst •

Syntheses Home