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Total synthesis of Strychnine:
Reference: Solé, D.; Bonjoch, J.; García-Rubio, S.; Peidró, E.; Bosch, J. Chem. Eur. J. 2000, 6, 655. DOI
Keywords: Ketone → EnolSilane • N-C(O)OR → N-Me • Lactam-6 • Ketone-1,3-di enolate+Aryl-X • Ketone-1,3-di enolate+Alkyl-X • Alkyl-X+Enolate • Reductive amination, asym • Amine-5 • N-Bn → N-C(O)OR • EnolSilane → Ketone-α-SeR • Selenoxide-Ei → Enone • N-H → N-Allyl • Pd-Heck reductive • Amine-6 • Claisen acylation, Mander • Ketone enolate+Mander • Mander+enolate • Nitro → Amine • Reductive amination, Zn • Indole synthesis • CarboxEster epimerization • CarboxEster → Aldehyde • Mechanism • Knoevenagel condensation • Lactam-6 • Ether-7 • Claisen-Enol ether • Ozonolysis • O-SiMe2tBu → O-H •
Reagents: Carbonate, potassium • Allyl-Br • Carbonate, potassium • O3 • BH3CN-Na+ • NH(SiMe3)2 (HMDS) • SePh-Cl • O3 • Vinyl-I • Allyl-Br • Pd(OAc)2 • NEt3 • LiN(SiMe3)2 • HMPA (solvent) • O=C(OR)CN • H2SO4 • NaH • AlHiBu2 • Malonate • Acetate, sodium • NHiPr2 • Iodide, lithium •

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