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Total synthesis of Strictamine New:
Reference: Ren, W.; Wang, Q.; Zhu, J. Angew. Chem. Int. Ed. 2016, 55, 3500. DOI
Keywords: Alkene → Diol-1,2 • Diol-1,2 cleavage • Reductive amination, B-H • Ketone → Ketone-α-Halo • Ketone → Ketone-α-NR2 • Ammonium → Amine • N-Me → N-C(O)OR • Nitro → Amine • Amine → Imine • Pd-Carboxylation • N-H → N-Allyl • Ni-Heck coupling •
Reagents: OsO4, NMO • Periodate, sodium • NHMe2 • BH(OAc)3-Na+ • TsOH • NBS • Iodide, sodium • DMSO (solvent) • Carbonate, potassium • O=C(OAllyl)Cl • Iodide, sodium • TiCl3 • Acetate, ammonium • Pd(PPh3)4 • NEt3 • Carbonate, cesium • Ni(cod)2 • HSiEt3 • NEt3

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