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Total synthesis of Spongistatin 1 - (Part 2):
Reference: Smith, A. B.; et al Tetrahedron Lett. 1997, 38, 8667, 8671, 8675. DOI, DOI, DOI, Part 1
Keywords: EnoateEster → Allyl-OH • B-Allyl-Ipc+Aldehyde • Aldol-B-Ipc • Iodolactonization • Li-Dithiane+Epoxide • Li-Sulfone+Alkyl-X • Alkyl-X+Li-R • Wittig-carboxymethyl → EnoateEster • Julia-Type II • B-Allyl-Tartrate+Aldehyde • Aldol-B-Tartrate •
Reagents: Allyl-B(Ipc)2 • H2O2, NaOH • Boc2O • IBr • Epoxide • PPh3=C(Me)-CO2R • AlHiBu2 • BuLi(tert) • Epoxide • Epoxide • Crotyl-B(tartrate) • LiCHR-Sulfonyl • BuLi(n), HMPA • BuLi(n) • I-CH2-MgX •

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