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Total synthesis of Sarkomycin:
Reference: Mikolajzyk, M.; Zurawinski, R.; Kielbasinski, P. Tet. Lett. 1989, 30, 1143. DOI
Keywords: Regitz diazo transfer • Jones oxidation • Aldehyde → CarboxAcid • HWE → Enone • KetoPhosphonate dianion+Alkyl-X • Alkyl-X+Enolate • Ozonolysis • Regitz diazo transfer • Diazoketone, insertion •
Reagents: P(O)(OR)2CHR-C(O)R' • NaH • BuLi(n) • NaH • Azide, sulfonyl • O3 • Me2S • CrO3, H2SO4 (Jones) • Acetone (solvent) • P(O)(OR)2CHR-C(O)R' • NaH • Formaldehyde • Diazophosphonate • Rh2(OAc)4

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