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Total synthesis of Rubrobramide:
Reference: Mizutani, S.; Komori, K.; Taniguchi, T.; Monde, K.; Kuramochi, K.; Tsubaki, K. Angew. Chem. Int. Ed. 2016, 55, 9553-9556. DOI
Keywords: Mechanism • Darzens • Ketone → Ketal • CarboxEster → CarboxAmide • CarboxAmide → CarboxAmide-α-Br • ConjAdd M-OR • Epoxide → Diol •
Reagents: Glycol, bistrimethylsilylether • SiMe3-OTf • NH(SiMe3)2 (HMDS) • NBS • Glyoxal • NEt3 • TsOH •

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