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Total synthesis of Roseophilin:
Reference: Harrington, P. E.; Tius, M. A. J. Am. Chem. Soc. 2001, 123, 8509-8514. DOI
Keywords: Aldehyde -> Imine • Imine -> Aldehyde • Pinnick oxidation • Aldehyde -> CarboxAcid • Peterson -> Enal • Knorr • Pyrrole synthesis • N-SEM -> N-H • N-SiR3 -> N-H • Aldehyde azaenolate+Silyl-Cl • RCM -> Ring-C • Li-Aryl+Ketone • Hydrogenation Alkene • Li-Aryl -> Ce-Aryl • Li-Allenyl/Propargyl+CarboxAmide • CarboxAmide+Li-R • CarboxAcid -> CarboxAmide • N-H -> N-SEM • Nazarov • Stetter •
Reagents: NH2tBu • LiNiPr2 • LiNiPr2 • Oxalic acid • Chlorite, sodium • PPh3, CBr4 • PCy3 • PCy3 • H2, Pd • Acetate, ammonium • KH • Furyl-Li • Fluoride, Bu4N+ • HCl, H2O • Grubbs I • CeCl3 • SiMe3-Cl • DMF (solvent) • Hexafluoroisopropanol (solvent) • Benzoyl peroxide • Thiazolium • DMAP •

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