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Total synthesis of Quadrone :
Reference: Takeda, K.; Shimono, Y.; Yoshii, E. J. Am. Chem. Soc. 1983, 105, 563. DOI
Keywords: Ketone -> Enolsilane • O-Me -> O-H • CarboxAcid -> CarboxEster • Aldol-Na -> Enone • Alkyne Hydration • Al-Allenyl/Propargyl+Ketone • Felkin-Anh • Enolsilane+Alkyl-X • DeMayo cycloaddition • Photochemistry 2+2 • Jones oxidation • Alkyl-OH -> CarboxAcid • Alkyl-OH -> Ketone • Wagner-Meerwein • Mechanism •
Reagents: Photochemistry • LiNiPr2 • Cl-CH2-OR • Allenyl-AlR2 • Propargyl-Br • HgO • NaH • BBr3 • CrO3, H2SO4 (Jones) • Diazomethane • CH2I2, Zn/Cu • SiMe3-Cl • Acetone (solvent) • Formic acid • Hydroxide, sodium • CrO3Cl·PyH (PCC) •

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