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Total synthesis of Pumiliotoxin C (Overman):
Reference: Overman, L. E.; Jessup, P. J. J. Am. Chem. Soc. 1978, 100, 5179. DOI
Keywords: HWE → Enone • Reductive amination, H2 • Amine-6 • N-H → N-Alkyl • Bicyclo(440)-aza • Hydrogenation Enone • Hydrogenation Imine • Imine → Amine • Diels-Alder, Enone • N-C(O)OR → N-H •
Reagents: P(O)(OR)2CH2-C(O)R' • NaH • H2, Pd • HBr • H2, Pt • Crotonate • Butadiene, 1-NR2

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