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Total synthesis of Prelog-Djerassi Lactonic Acid:
Reference: Evans, D. A.; Bartroli, J. Tetrahedron Lett. 1982, 23, 807-810. DOI
Keywords: CarboxAmide(Evans) -> Alkyl-OH • Alkyl-OH -> Aldehyde • O-H -> O-SiMe3 • Hydroboration Alkene • O-SiMe3 -> O-H • Alkyl-OH -> CarboxAcid • Lactone-6 • CarboxAmide(Evans) -> CarboxAcid • CarboxAmide enolate(Evans)+Alkyl-X • Aldol-B-Evans •
Reagents: LiNiPr2 • AlH4-Li+ • DMSO, Py·SO3 • DMAP • BH2(Thexyl) • H2O2 • Oxalic acid • NMO • RuCl2(PPh3)2 • Hydroxide, lithium •

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