image

Total synthesis of Pipecolic Acid:
Reference: Carlson, E. C.; Rathbone, L. K.; Yang, H.; Collett, N. D.; Carter, R. G. J. Org. Chem. 2008, 73, 5155. DOI
Keywords: Mg-Alkyl+Aldehyde • Aldehyde+Mg-R • Olefin cross metathesis • ConjAdd Amine • Amine-6 • Alkyl-OH → Ketone • N-Cbz → N-H •
Reagents: Crotonaldehyde • Grubbs II • Grubbs II • Chiral catalyst • MeMgBr • Dess-Martin • H2, Pd •

Syntheses Home