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Total synthesis of Physostigmine (partial):
Reference: Espejo, V. R.; Li, X.-B.; Rainier, J. D. J. Am. Chem. Soc. 2010, 132, 8283. DOI
Keywords: N-Boc → N-H • Cyclopropane • Bromoamination Alkene • Amine-5 • CarboxAcid → CarboxEster • N-H → N-Me • Reductive amination, H2 • Cyclopropane alkylation • Radical reduction(C-OR) • Alkyl-OH → Alkyl-H(2°) • Barton-McCombie reduction •
Reagents: NBS • Pyridine • KOtBu • Hydroxide, sodium • Thiol, t-butyl • SiMe3-I • Formaldehyde • H2, Pd • AlMe3

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