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Total synthesis of Physostigmine New:
Reference: Espejo, V. R.; Li, X.-B.; Rainier, J. D. J. Am. Chem. Soc. 2010, 132, 8283. DOI
Keywords: N-Boc -> N-H • Barton decarboxylation • C-CO2H -> C-H • Cyclopropane • Bromoamination Alkene • Amine-5 • CarboxAcid -> CarboxEster • N-H -> N-Me • Reductive amination, H2 • Cyclopropane alkylation •
Reagents: NBS • Pyridine • KOtBu • Hydroxide, sodium • HS-tBu • SiMe3-I • Formaldehyde • H2, Pd • AlMe3

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