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Total synthesis of Phenserine:
Reference: Huang, A.; Kodanko, J. J.; Overman, L. E. J. Am. Chem. Soc. 2004, 126, 14043. DOI
Keywords: Ketal → Diol-1,2 • Diol-1,2 cleavage • ArylO-Me → ArylO-H • O-H → O-C(O)NR2 (phenol) • Lactam enolate+Alkyl-X • Alkyl-X+Enolate • Reductive amination, Al-H • Amine-5 • N-H → N-Alkyl •
Reagents: KN(SiMe3)2 • DMPU (solvent) • TsOH • Periodate, sodium • NH2Me • AlH4-Li+ • B(Br)3 • NaH • Isocyanate •

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