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Total synthesis of Nootkatone:
Reference: Marshall, J. A.; Ruden, R. A.. J. Org. Chem. 1971, 36, 594. DOI
Keywords: Ketal → Ketone • Wittig-methyl • CompE+-Ketone/Enone+Wittig • Wittig-alkyl+Ketone • CompE+-Ketone/CarboxEster+Wittig • Dieckmann • CarboxEster enolate+CarboxEster • Pinacol • Wolff-Kishner • Ketone → CH2 • Robinson annulation, ketoester • KetoEster enolate+Enone • Cyclohexenone • Enone → Ketal • Epoxidation, peracid • CompOx-Alkene/Alkene+Peracid • Ketone → Ketal • Ketal → Ketone • CarboxEster → Alkyl-OH • Alkyl-OH → Aldehyde •
Reagents: Orthoformate • NaH • PPh3=CH-Me • Perbenzoic acid, 3-chloro • BF3·OEt2 • Carbonate, sodium • Glycol • TsOH • AlH4-Li+ • Carbodiimide • Hydrazine • PPh3=CH2 • KOtAm •

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