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Total synthesis of Nootkatone:
Reference: Dastur, K. P. J. J. Am. Chem. Soc. 1974, 95, 2605-.2608 DOI
Keywords: Cationic cyclization • Birch reduction • Diels-Alder, EnoateEster • Allylic oxidation → Enal • Wittig-methyl • Li-Me+CarboxEster • CarboxEster+Li-R • Grob fragmentation • Dehydroacetoxylation → Ene • Ester Pyrolysis •
Reagents: Li°/NH3 • Acrylate • SeO2 • PPh3=CH2 • MeLi • Formic acid • Collidine • Al2O3

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