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Total synthesis of Minfiensine:
Reference: Jones, S. B.; Simmons, B.; MacMillan, D. W. C. J. J. Am. Chem. Soc. 2009, 131, 13606–13607. DOI
Keywords: N-H → N-PMB • Li-Aryl+CarboxAmide • CarboxAmide+Li-R • Enal → Allyl-OH • O-H → O-SiEt3 • Hydrogenation Allene • O-SiEt3 → O-H • N-PMB → N-H • Li/H → Li-Indole • Radical cyclization(Alkyl) • Reductive amination, B-H • Diels-Alder, Yne • Mechanism • Amine-5 • Amine-6 • HWE → EneSulfide •
Reagents: NaH • PMB-Cl • BuLi(n) • DMF (react) • NaH • BH4-Na+, CeCl3 • SiEt3-OTf • Propiolaldehyde • BH(OAc)3-Na+ • HSntBu3 • AIBN • H2, Pd • Thiol, phenyl • Acetic acid, trifluoro • Propiolaldehyde • Chiral catalyst • P(O)(OR)2CH2-SR •

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