image

Total synthesis of Mesembrane:
Reference: Pearson, W.H.; Szura, D. P.; Potich, M. J. J. Am. Chem. Soc. 1992, 114, 1329. DOI
Keywords: CarboxEster → Alkyl-OH • Alkyl-OH → Aldehyde • Staudinger • Hydrogenolysis C-S • Aldehyde → Imine • Azide → Amine • HWE → EneSulfide • Li/Sn → Li-Amine • Azaallyl anion Cycloaddition • Amine-5 •
Reagents: AlH4-Li+ • DMSO, (COCl)2 (Swern) • PPh3 • RaNi • MeLi • MeI •

Syntheses Home