| Reference: | Mandell, L.; Gresham, J. T.; Freeman, W. J. J. Am. Chem. Soc. 1965, 87, 8234–8236. DOI |
| Keywords: | Ketoester -> Enamine • Reductive amination, H2 • CarboxEster -> Carboxamide • Lactam-6 • Dieckmann • CarboxEster enolate+CarboxEster • Amine-6 • Decarboxylation • Enamine ConjAdd • Ketone enamine+EneNitrile • Reductive amination, H2 • Mechanism • Amine-6 • |
| Reagents: | H2, Pt • NaH • Acetic acid • Pyrrolidine • Acrylonitrile • H2, Pd • Acetic acid • HCl • |