| Reference: | Kornfeld, E. C.; Fornefeld, E. J.; Kline, G. B.; Mann, M. J.; Jones, R. G.; Woodward, R. B. J. Am. Chem. Soc. 1954, 76, 5256. DOI |
| Keywords: | CarboxAcid -> CarboxCl Friedel-Crafts Acylation Ketone -> Ketone-α-Halo Ketal -> Ketone N-C(O)R -> N-H N-H -> N-C(O)R Aldol-Na -> Enone Amine-6 Enone -> Allyl-OH CarboxEster -> CarboxAcid N-H -> N-Alkyl Ketone-α-Halo -> Ketone-α-NR2 Allyl-OH -> Allyl-Cl Allyl-X -> Allyl-CN Nitrile -> CarboxEster |
| Reagents: | SOCl2 AlCl3 Bromine NaOMe Acetyl chloride BH4-Na+ SOCl2 HCN Hydroxide, potassium RaNi |