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Total synthesis of Lysergic Acid New:
Reference: Kornfeld, E. C.; Fornefeld, E. J.; Kline, G. B.; Mann, M. J.; Jones, R. G.; Woodward, R. B. J. Am. Chem. Soc. 1954, 76, 5256. DOI
Keywords: CarboxAcid -> CarboxCl • Friedel-Crafts Acylation • Ketone -> Ketone-α-Halo • Ketal -> Ketone • N-C(O)R -> N-H • N-H -> N-C(O)R • Aldol-Na -> Enone • Amine-6 • Enone -> Allyl-OH • CarboxEster -> CarboxAcid • N-H -> N-Alkyl • Ketone-α-Halo -> Ketone-α-NR2 • Allyl-OH -> Allyl-Cl • Allyl-X -> Allyl-CN • Nitrile -> CarboxEster •
Reagents: SOCl2 • AlCl3 • Bromine • NaOMe • Acetyl chloride • BH4-Na+ • SOCl2 • HCN • Hydroxide, potassium • RaNi •

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