image

Total synthesis of Lycoricidine:
Reference: Hudlicky, T.; Olivo, H. F. J. Am. Chem. Soc. 1992,114, 9694-9696. DOI
Keywords: N-OH → N=O • Diels-Alder, Nitroso • Nitroso Cycloaddition • N-OR → N-H • Pd-Heck coupling • Lactam-6 • N-Cbz → N-H • Acetal → Diol • O-SiMe2iPr → O-H • Alkene → Diol-1,2(asym) •
Reagents: Enzyme • Acetone (react) • TsOH • Iodide, R4N+ • Al(Hg) • Pd(OAc)2 • Acetic acid, trifluoro •

Syntheses Home