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Total synthesis of Lineatin:
Reference: Baeckstrom, P.; Li, L.; Polec, I.; Unelius, C. R.; Wimalasiri, W. R. J. Org. Chem. 1991, 56, 3358. DOI
Keywords: CarboxEster -> CarboxAcid • Alkene isomerization • Ketone -> Alkyl-OH • O-H -> O-C(O)R • Alkene -> Diol-1,2 • Alkene cleavage • Aldehyde -> Acetal(Me) • Dehydration -> Ene • Ether-6 • HWE -> EnoateEster • Claisen-Enol ether • Mg-Alkyl+Ketone • Mechanism • Ketene Cycloaddition • Cyclobutane •
Reagents: Formic acid • P(O)(OR)2CH2-CO2R • Hydroxide, potassium • Pd/C • AlH4-Li+ • Acetic anhydride, Py • OsO4 • Periodic acid • MeMgBr • HCl • Acetate, sodium •

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