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Total synthesis of Laurencin:
Keywords: Orthoester → CarboxEster • CarboxEster → CarboxAcid • O-H → O-Allyl • Wittig-alkyl → Ene-cis • Protecting group - CarboxAcid • Li/H → Li-Allyl-X • Li-R → B-R • CarboxAmide(Weinreb) → Aldehyde • B-Allyl+Aldehyde • Ether-8 • Protecting group - Aldehyde • Alkyl-OH → Aldehyde • CarboxAcid → CarboxAmide(Weinreb) • Alkyl-OH → Aldehyde •
Reagents: Acetonitrile, trichloro • AlH4-Li+ • Dess-Martin • PPh3=CH-Alkyl • Bisulfate, sodium • Hydroxide, lithium • Carbodiimide • NMe(OMe)-H • AlHiBu2 • BuLi(sec) •

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