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Total synthesis of Jiadifenolide:
Reference: Lu H.; Martinez M. D.; Shenvi R. A. Nature Chem. 2015, 7, 604-607 DOI
Keywords: Ketone → Alkyl-OH • Ketone → EnolSilane • Pauson-Khand (hetero) • Knoevenagel condensation • Ozonolysis • CompOx-Alkene/Alkyne+O3 • ConjAdd Enolate • Aldehyde → Alkyne (-H2O) • Ketoester enolate+EnoateEster • Ketoester dianion+Alkyl-X • CarboxEster → CarboxEster-α-Br • CarboxEster enolate+Br2 • CarboxEster → CarboxEster-α-OH • CarboxEster → CarboxEster-α-OH •
Reagents: Phosphazene base • O3 • SiO2 • Mo(CO)6 • Bromide, R4N+ • LiNiPr2 • Ti(OiPr)4 • Perbenzoic acid, 3-chloro • BH(OAc)3-Me4N+ • CBr4 • Oxaziridine • NaSi(NMe2)3 • Sulphonyl fluoride, perfluorobutyl •

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