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Total synthesis of HPA-12:
Reference: Snider, J. R.; Entrekin, J. T.; Snowden, T. S.; Dolliver, D. Synthesis 2013, 45, 1899-1903. DOI
Keywords: Friedel-Crafts Acylation • Ketone → Alkyl-OH • Epoxidation • Epoxide+Azide • Lactone-5 • N-H → N-C(O)R • Staudinger • Mechanism •
Reagents: AlCl3 • BH(OAc)3-Me4N+ • Acetic acid • PPh3 • BH4-Na+ • Hydroxide, sodium • Azide, sodium •

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