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Total synthesis of Herboxidiene (partial):
Reference: Smith, N. D.; Kocienski, P. J.; Street, S. D. A. Synthesis 1996, 652. DOI
Keywords: Ti-Allyl+Aldehyde • Felkin-Anh • Li/I → Li-Alkyl • Metalate rearrangement (Cu) • Julia-Kocienski • Li/H → Li-Vinyl-OR • Li/H(asym) → Li-Allyl • Li-Allyl → Ti-Allyl • Cu-Vinyl+Alkyl-X • Alkyl-X+Cu-R •
Reagents: Allyl-Li • Ti(OiPr)4 • Lactaldehyde • Vinyl-Li • BuLi(tert) • SnBu3-Cl • Vinyl-SnR3 • Alkyl-Li • BuLi(tert) • CuI • MeI •

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