image

Total synthesis of Griseofulvin (Stork):
Reference: Stork, G.; Tomasz, M. J. Am. Chem. Soc. 1962, 84, 310-312. DOI
Keywords: Li-Alkynyl+Aldehyde • Propargyl-OH → Ynone • ConjAdd Enolate • Ketone enolate+Ynone • Ynone+Enolate • Ketone enolate+Enone • Cyclohexenone •
Reagents: Crotonaldehyde • Alkynyl-Li • MnO2 • KOtBu •

Syntheses Home