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Total synthesis of Frullanolide:
Reference: Still, W. C.; Schneider, M. J. J. Am. Chem. Soc. 1977, 99, 948. DOI
Keywords: Wharton transposition • Epoxidation, nucleophilic Enone • Iodolactonization • Furst-Plattner diaxial • Lactone-5 • Dehydrohalogenation → Ene • Hofmann elim → Enoate • ConjAdd Amine • Claisen-Ireland • Mechanism •
Reagents: H2O2, NaOH • Hydrazine • BuLi(n) • Acryloyl-Cl • Pyrrolidine • Me2SO4 • Hydroxide, potassium • I2, KI • DBU • LiNiPr2 • SiEt3-Cl •

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