image

Total synthesis of Fichtelite:
Reference: Taber, D. F.; Saleh, S. A. J. Am. Chem. Soc. 1980, 102, 5085. DOI
Keywords: Ketone -> Alkyl-OH • Birch alkylation • CarboxAcid enolate+Alkyl-X • Cu-Vinyl+Enone • ConjAdd Cu-R • Aldol-Li -> Enone • Ketone enolate+Aldehyde • Cu-Me+Enone • ConjAdd Cu-R • Mechanism • Hydrogenation Alkene • Alkyl-OH -> Alkyl-H • Diels-Alder, Intram •
Reagents: Li°/NH3 • Propenyl-Li • CuBr·SMe2 • LiNiPr2 • Acetaldehyde • TsOH • LiCuMe2 • AlHiBu2 • SO2Cl2 • NHMe2 • Na°/NH3 • H2, Pt • Oxalic acid •

Syntheses Home