image

Total synthesis of Epothilone B, D (Part 2):
Reference: White, J. D.; Carter, R. G.; Sundermann, K. F.; Wartmann, M.. J. Am. Chem. Soc. 2001, 123, 5407. DOI (Part 1)
Keywords: CarboxEster → CarboxAcid • O-SiMe2tBu → O-H • O-SiMe2tBu → O-H • Diimide+Alkene • CompRed-Alkene/Alkene+Diimide • Yamaguchi lactonization • Lactone-9+ • Epoxidation, dioxirane •
Reagents: Hydroxide, sodium • Fluoride, R4N+ • Benzoyl chloride, 2,4,6-trichloro • Acetic acid, trifluoro • Acetic acid • Diimide • Dioxirane •

Syntheses Home