image

Total synthesis of Epibatidine:
Reference: Clayton, S. C.; Regan, A. C. Tetrahedron Lett. 1993, 7493. DOI
Keywords: Hydrogenation alkene • EneSulfone → Vinyl-H • N-C(O)OR → N-H • Diels-Alder, Yne • Amine-5 • Pd-Heck coupling •
Reagents: H2, Pd • Na(Hg) • HBr • Pd(OAc)2 • Formic acid •

Syntheses Home