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Total synthesis of Epibatidine (Regan):
Reference: Clayton, S. C.; Regan, A. C. Tetrahedron Lett. 1993, 7493. DOI
Keywords: Diels-Alder, Yne • Amine-5 • Pyrrole cycloaddition • Bicyclo(221) • Pd-Heck coupling • Hydrogenation alkene • CompRed-Alkene/Aldehyde+H2 • EneSulfone → Vinyl-H • N-C(O)OR → N-H •
Reagents: Alkynyl-Sulfone • H2, Pd • EneSulfone • Na(Hg) • HBr • Pd(OAc)2 • Formic acid •

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