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Total synthesis of Epibatidine:
Reference: Aggarwal, V. K.; Olofsson, B. Angew. Chem. Int. Ed. 2005, 44, 5516 –5519. DOI
Keywords: O-H → O-SO2R • N-Boc → N-H • Asymmetric Deprotonation • Ketone enolate+Aryl-X • Ketone → Alkyl-OH • N-H → N-Alkyl(2°) •
Reagents: Chiral base • LiN(Phenethyl)R • BH4-Na+ • Sulfonyl chloride, methane, NEt3 • Acetic acid, trifluoro • Chiral base •

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