image

Total synthesis of Cytisine:
Reference: Stead, D.; O'Brien, P.; Sanderson, A. J. Org. Lett. 2005, 7, 4459-4462. DOI
Keywords: N-Boc -> N-H • N-Bn -> N-H • Mannich • Amine-6 • Li/H -> Li-Amine • RCM -> Lactam • Lactam-6 • Wolff-Kishner • Ketone -> CH2 • Pd-Dehydrogenation • Cu-Amine+Allyl-OP(O)(OR)2
Reagents: NH2Bn • Formaldehyde • Hydrazine, tosyl • BH4-Na+ • BuLi(sec), TMEDA • CuCN • Allyl-Phosphate • Acetic acid, trifluoro • Acryloyl-Cl • Grubbs I • Pd/C •

Syntheses Home