image

Total synthesis of Cocaine:
Reference: Tufariello, J.J.; Mullen, G. B. J. Am. Chem. Soc. 1978, 100, 3638. DOI
Keywords: Dehydration → Enoate • Amine → Ammonium • N-OR → N-H • O-H → O-C(O)R • Nitrone synthesis • Nitrone Cycloaddition • Nitrone Cycloaddition • Nitrone Retro-Cycloaddition • Retro-1,3-dipolar cycloaddition • Nitrone Cycloaddition • Amine-6 •
Reagents: Perbenzoic acid, 3-chloro • Acrylate • MeSO2Cl • DBN • MeI • Zn° • Benzoyl chloride •

Syntheses Home