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Total synthesis of Cocaine (Tufariello):
Reference: Tufariello, J. J.; Mullen, G. B. J. Am. Chem. Soc. 1978, 100, 3638. DOI
Keywords: Nitrone synthesis • Nitrone Cycloaddition • Nitrone Cycloaddition • Nitrone Retro-Cycloaddition • Retro-1,3-dipolar cycloaddition • Nitrone Cycloaddition • Amine-6 • Bicyclo(321) • N-OR → N-H • O-H → O-C(O)R • Amine → Ammonium • Dehydration → Enoate •
Reagents: Perbenzoic acid, 3-chloro • Acrylate • Sulfonyl chloride, methane, Py • DBN • MeI • Zn° • Benzoyl chloride •

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