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Total synthesis of Cephalotaxine:
Reference: Isono, N,; Mori, M. J. Org. Chem. 1995, 60, 115-119. DOI
Keywords: N-H -> N-Boc • N-Boc -> N-H • CarboxEster -> Alkyl-OH • Alkyl-OH -> Aldehyde-α-NR2 • Aryl-OMe -> Aryl-OH • Diol -> Acetal • Alkene -> Diol-1,2 • Alkyl-OH -> Ketone-α-OR • Enone -> Allyl-OH • Lactone enolate+Alkyl-X • Amine+Alkyl-X • Si-Vinyl -> Vinyl-I • Ketone-1,2-di • Ketone -> Enolether • Friedel-Crafts Alkylation • Amine-7 • Sn-Vinyl+Aldehyde • Aldehyde+Sn-R •
Reagents: LiNiPr2 • Allyl-Br • ICl • Fluoride, potassium • H2SO4 • Boc2O • Diazomethane • Acetic acid, trifluoro • NEt3 • AlH4-Li+ • DMSO, Py·SO3 • BBr3 • CH2Br2 • NMe3(O) • DMSO, (CF3CO)2O • Orthoformate • BH4-Na+ • Acetic acid, trifluoro • DMSO (solvent) • Polyphosphoric acid • SnBu3-SiMe3 • Fluoride, cesium •

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