image

Total synthesis of Cedrene:
Reference: Lee, H. -Y.; Lee, S.; Kim, D.; Kim, B. K.; Bahn, J. S.; Kim, S. Tetrahedron Lett. 1998, 39, 7713-7716. DOI
Keywords: Ketone → EnolSilane • Saegusa Oxidation • Ketone → Enone • Aldehyde enamine+Enone • Enone+Enamine • Aldehyde+Mg-R • Mg-Alkyl+Aldehyde • O-H → O-C(S)SR • Ketone → Hydrazone • Radical cyclization(Alkyl) • Ketal → Ketone • Dehydration → Ene • Ketone+Li-Alkyl • Li-Me+Ketone • Mechanism •
Reagents: LiNiPr2 • Pd(OAc)2 • SiMe2tBu-OTf • NaH • CS2 • Aziridine • HSnBu3 • AIBN • TsOH • MeLi • SOCl2 • TsOH •

Syntheses Home