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Total synthesis of Camptothecin:
Reference: Boch, M.; Korth, T.; Nelke, J. M.; Pike, D.; Radunz, H.; Winterfeldt, E. Chem. Ber. 1972, 105, 2126-2142 DOI
Keywords: CarboxAcid → CarboxAmide • Ketone → EnolEther • Amine-5 • Lactone enolate+Alkyl-X • Alkyl-X+Enolate • Claisen acylation, ester • Lactam-6 • ConjAdd-Elimination • Quinoline synthesis • CarboxEster → Alkyl-OH • Decarboxylation • Lactone-6 • Lactone → Lactone-α-OH • Aryl-Cl → Aryl-H • Mechanism •
Reagents: Carbodiimide • KOtBu • Diazomethane • Malonate • NaH • NaH • O2 • SOCl2 • AlHiBu2 • BH4-Na+ • Acetic acid, trifluoro • NaH • CuCl2 • NHMe2 • H2, Pd •

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