image

Total synthesis of Camptothecin:
Reference: Boch, M.; Korth, T.; Nelke, J. M.; Pike, D.; Radunz, H.; Winterfeldt, E. Chem. Ber. 1972, 105, 2126-2142 DOI
Keywords: CarboxAcid -> CarboxAmide • Ketone -> Enolether • Amine-5 • Claisen acylation, ester • ConjAdd-Elimination • Quinoline synthesis • CarboxEster -> Alkyl-OH • Decarboxylation • Lactone-6 • Lactone -> Lactone-α-OH • Aryl-Cl -> Aryl-H •
Reagents: Carbodiimide • KOtBu • Diazomethane • NaH • NaH • O2 • SOCl2 • AlHiBu2 • BH4-Na+ • Acetic acid, trifluoro • CuCl2 • NHMe2 • H2, Pd •

Syntheses Home