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Total synthesis of Camptothecin, dl:
Reference: Volkmann, R.; Danishefsky, S.; Eggler, J.; Solomon, D. M. J. Am. Chem. Soc. 1971, 93, 5576–5577. DOI
Keywords: Acetal → Aldehyde • Aldehyde → CarboxAcid • CarboxAcid → CarboxEster • Dieckmann • CarboxEster enolate+CarboxEster • Friedlander • Quinoline synthesis • ConjAdd Amine • ConjAdd Enamine • Lactam-6 • Decarboxylation • CarboxEster enolate+Alkyl-X • Enamine+Aldehyde • Ketone → Ketone-α-OR • Ketone enolate+(Ox) • Decarboxylation •
Reagents: NEt3 • HCl, H2O • CrO3, H2SO4 (Jones) • HCl, MeOH • NaOMe • HCl, H2O • Hydroxide, sodium • CuO • NaH • Formaldehyde • H2SO4 • KOtBu • DMSO (solvent) • H2O2

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