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Total synthesis of Camptothecin:
Reference: Curran, D. P.; Ko, S. B.; Josien, H. Angew. Chem., Int. Ed. Engl. 1996, 34, 2683. DOI
Keywords: Alkene → Diol-1,2 • Lactam-6 • Pd-Heck coupling • Li/H → Li-Pyridyl • Li-Aryl+CarboxAmide • CarboxAmide+Li-R • Sharpless dihydroxylation • Alkene → Diol-1,2(asym) • Lactone-6 • Si-Aryl → I-Aryl • N-H → N-Propargyl • Reductive etherification • Radical cyclization(Vinyl) • Quinoline synthesis • Isocyanide radical • Mechanism •
Reagents: BuLi(tert) • DMF (solvent) • BuLi(n) • I2 • HSiEt3 • Acetic acid, trifluoro • Pd(OAc)2 • Carbonate, potassium • Bromide, R4N+ • OsO4 • Pyridine • Carbonate, calcium • I2 • SiMe3-I • Bromide, lithium • DMF (solvent) • Propargyl-Br • Pyridyl-Li • Isocyanide • SnMe3-SnMe3 • Photochemistry •

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