image

Total synthesis of Camptothecin:
Reference: Comins, D. L.; Hong, H.; Jianhua, G. Tetrahedron Lett. 1994, 35, 5331. DOI
Keywords: Aldehyde → Alkyl-OH • Lactone-6 • Li/I → Li-Aryl • Li/H → Li-Quinoline • Li-Aryl+Ketone • Li-Aryl+Aldehyde • CompE+-Ketone/CarboxEster+Li-R • Hydrogenolysis C-Cl • Mitsunobu → Amine • Benzyl-OH → Benzyl-NR2 • Li-Aryl → I-Aryl • Li/H → Li-Pyridyl • Li-Aryl+CarboxAmide • CarboxAmide+Li-R • Radical cyclization(Acyl) •
Reagents: BH4-Na+ • Pyridyl-Li • BuLi(n) • BF3·OEt2 • HCl, H2O • H2, Pd • LiNiPr2 • Formaldehyde • PPh3, DEAD • BuLi(n) • DMF (react) • BuLi(n) • I2 • Pyridyl-Li • HSnBu3 • AIBN •

Syntheses Home