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Total synthesis of Camptothecin:
Reference: Curran, D. P.; Ko, S. B.; Josien, H. Angew. Chem., Int. Ed. Engl. 1995, 34, 2683.
Keywords: Alkene -> Diol-1,2 --- Lactam-6 --- Pd-Heck coupling --- Radical cyclization(Vinyl) --- Li/H -> Li-Pyridyl --- Li-Aryl+CarboxAmide --- Sharpless dihydroxylation --- Alkene -> Diol-1,2(asym) --- Lactone-6 --- Si-Aryl -> Aryl-I --- Quinoline synthesis --- Isocycanide radical --- N-H -> N-Propargyl --- Reductive etherification
Reagents: BuLi(tert) --- DMF (react) --- BuLi(n) --- I2 --- HSiEt3 --- CF3CO2H --- Pd(OAc)2 --- Carbonate, potassium --- Bromide, Bu4N+ --- OsO4 --- Carbonate, calcium --- I2 --- SiMe3-I --- Bromide, lithium --- DMF (solvent) --- Propargyl-Br --- Isocyanide --- SnMe3-SnMe3 --- Photochemistry --- Pyridyl-Li

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