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Total synthesis of Biotin:
Reference: Fujisawa, T.; Nagai, M.; Koike, Y.; Shimizu, M. J. Org. Chem. 1994, 59, 5865
Keywords: N-Boc -> N-H --- N-H -> N-C(O)NR2 --- O-H -> O-SO2R --- Li-Alkynyl+Aldehyde --- Hydrogenation-Enesulfide --- Felkin-Anh Chelation control --- N-H -> N-Alkyl(2°) --- Alkyne Hydrosulfidation --- Sulfide-5
Reagents: Alkynyl-ZnX --- TsOH --- Isocyanate --- KH --- HMPA (solvent) --- TsOH --- Hydroxide, cesium --- H2, Pd --- HBr --- Microbial oxidation

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