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Total synthesis of Aspidospermine Model:
Reference: Magnus, P.; Cairns, P. M.; Kim, C. S. Tetrahedron Lett., 1985, 26, 1963. DOI
Keywords: Retro-Diels-Alder → Alkene • Pummerer • Amine-5 • Singlet oxygen+Diene • Furan+Singlet oxygen • Diels-Alder, Intram, o-Xylylene • Lactam-6 • Decarboxylative elimination • Aldehyde → Imine • CarboxAcid → CarboxAmide • Lactam-6 • Wittig-methyl • Diels-Alder, EnoateEster • Bicyclo(221) • CarboxAcid → CarboxCl • Sulfide → Sulfoxide •
Reagents: Perbenzoic acid, 3-chloro • Acetic anhydride, trifluoro • Sieves • O2 (singlet) • PPh3=CH2 • Oxalyl chloride • Cyclopentadiene •

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