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Total synthesis of Artemisinin:
Reference: Zhu, C.; Cook, S. P. J. Am. Chem. Soc. 2012, 134, 13577-13579. DOI
Keywords: Li-Vinyl+CarboxAmide • CarboxAmide+Li-R • Wacker oxidation • Alkene → Ketone • Shapiro reaction • ConjAdd-Alkylation • Enone+Cu-R • Cu-Alkyl+Enone • ConjAdd Cu-R • ConjAdd EnolSilane • Singlet oxygen+Alkene •
Reagents: Zn° • Cu(OTf)2 • Chiral catalyst • Allyl-Br • Hydrazine, tosyl • BuLi(n) • DMF (react) • Ketene acetal • AlEt2-Cl • H2O2 • Ketene acetal • MoO4(NH4)2 • H2O2, Mo • TsOH • O2 (singlet) •

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