image

Total synthesis of Amphoteronolide B (part):
Reference: Masamune; et al Tetrahedron Lett. 1988, 29, 451
Keywords: Alkyl-OH -> Ketone --- CarboxAcid -> CarboxEster --- Li-Phosphonate+Aldehyde --- HWE -> Dienone --- Lactone-15+
Reagents: P(O)(OMe)2CH2Li --- CrO3·Py2 (Collins) --- P(O)(OMe)2CH2-C(O)R --- Carbodiimide --- Carbonate, potassium --- Hydroxide, lithium --- DMAP --- 18-cr-6

Syntheses Home