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Total synthesis of Amphidinol 3 Fragment (Part 2):
Reference: Huckins, J. R.; Vicente, J.; Rychnovsky, S. D. Org. Lett. 2007, 9, 4757. DOI (Part 1)
Keywords: O-SiMe2tBu → O-H • O-H → O-SiMe2tBu • Nozaki-Hiyama coupling • Cr-Vinyl+Aldehyde • Aldehyde+Cr-R • Claisen-Ireland • O-H → O-C(O)R • CarboxAcid → CarboxAmide(Weinreb) • CarboxAmide(Weinreb)+Li-R • Li-Alkyl+CarboxAmide • Alkyl-OH → Aldehyde •
Reagents: Fluoride, R4N+ • Dess-Martin • Propenyl-Br • CrCl2 • Acetic anhydride, DMAP • SiMe2tBu-OTf • Acetic acid • NMe(OMe)-H • Carbodiimide • Ketene acetal •

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