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Total synthesis of Ajmalicine:
Reference: Van Tamelen, E. E.; Placeway, C. J. Am. Chem. Soc. 1961, 83, 2594. DOI
Keywords: Ketone → Alkyl-OH • Michael EnoateEster • Ketoester enolate+EnoateEster • Mannich • Lactam-6 • Hydrogenation Vinyl-NR2 • Amine-6 • Decarboxylation • Lactone-6 • Claisen acylation, formate • Aldehyde → Enol-R •
Reagents: Formaldehyde • POCl3 • H2, Pd • HCl • BH4-Na+ • Carbodiimide • Formate, ethyl • NaCPh3 • HCl, MeOH •

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