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Total synthesis of Ajmalicine:
Reference: Van Tamelen, E. E.; Placeway, C. J. Am. Chem. Soc. 1961, 83, 2594. DOI
Keywords: Michael EnoateEster • KetoEster enolate+EnoateEster • Mannich • Lactam-6 • Bischler-Napieralski • Amine-6 • Hydrogenation Enamine • Amine-6 • Decarboxylation β-keto acid • Lactone-6 • Claisen acylation, formate • Aldehyde → Enol-R • Ketone → Alkyl-OH •
Reagents: Acetoacetate • Formaldehyde • POCl3 • H2, Pd • HCl • BH4-Na+ • Carbodiimide • Formate, ethyl • NaCPh3 • HCl, MeOH •

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